Our current research focuses on the KRAS-variant, and other mutations like it.
The KRAS-variant is:
(1) an inherited, genetic marker that has significant implications for women’s health
(2) a predictor of endometriosis, associated infertility, and breast, ovarian and lung cancer
(3) a biomarker that identifies patients who will uniquely respond to agents used to treat cancer
Other mutations like the KRAS-variant have been shown to:
(1) Predict altered immunity
The KRAS-variant is unlike other known, inherited genetic markers. The latest research indicates the KRAS-variant's unique biology shows great potential for disease prevention because it can be influenced by certain exposures, particularly hormones.
MiraKind has research studies ready to launch to help determine the best ways to protect the health of individuals with the KRAS-variant.
Research questions include:
- What are the best cancer management strategies for KRAS-variant breast cancer patients?
- What environmental factors, hormone exposures, medicines, or other lifestyle factors can influence cancer risk for individuals with the KRAS-variant?
- How do individuals with the KRAS-variant respond differently to factors like hormone replacement therapy, birth control or IVF?
- How can cancer survivors who are positive for the KRAS-variant protect themselves from secondary cancers?
- How can we prevent cancers associated with the KRAS-variant for family members who are positive but have never been diagnosed with cancer?
What we know about the KRAS-variant:
- Associated with more cancer than any other known inherited genetic mutation
- Associated with advanced endometriosis and infertility
- Associated with a lifetime risk of breast cancer of > 20%, supporting eligibility for higher-level screening
- Associated with risk of developing two or more cancers in the same individual — the KRAS-variant is found in 50% of people with three separate cancers
- Associated almost always with post-menopausal ovarian cancer, allowing the opportunity for cancer prevention without lifestyle impact
- The genetic cause of cancer for over 50% of Hereditary Breast and Ovarian Cancer (HBOC) families without other known genetic causes, allowing relatives to be tested for a marker to know if they have inherited risk