Understanding Your Results
If you've received your KRAS-variant results, find out more about what your results mean for you.
I have the KRAS-variant but I've never had cancer.
Knowing you have the KRAS-variant puts you in the best position to make informed choices about advanced screening and lifestyle strategies to protect your health. While a positive test result indicates that your risk of breast, ovarian or lung cancer is about 2-6 times greater than the average woman, knowing you carry this gene mutation provides you and your doctor with powerful information that can be used to help minimize that increased risk.
This may mean:
- Working with your doctor to get higher level breast cancer screening (e.g. a breast MRI or ultrasound in addition to regular mammograms).
- Women who are menopausal or postmenopausal should continue gynecological screening of the ovaries, and may want to consider the option to have outpatient surgery to remove the fallopian tubes and ovaries if they and their physician thinks it is most appropriate.
- If you are already planning to get a hysterectomy, you may want to speak with your doctor about removing your ovaries at the same time.
- If you smoke, it’s especially important to consider strategies for stopping, as smoking further elevates your risk for multiple cancer types, especially lung cancer.
- If you are having your ovaries removed and are pre-menopausal or if you are currently going through menopause, you may want to talk with your doctor about continuing estrogen replacement therapy, as abruptly taking away estrogen appears to increase the risk of cancer for women with the KRAS-variant.
I have the KRAS-variant and have been diagnosed with cancer.
If you have been diagnosed with cancer and have tested positive for the KRAS-variant, this suggests that your cancer diagnosis could be associated with this genetic difference. Together with your physician, you can now use the information in several ways to protect your health and inform your decision making going forward.
- Women with the KRAS-variant appear to be at an elevated risk of an independent second cancer, so it is important to discuss the best screening and management strategies with your physician to minimize this risk.
- Many women live in fear of passing “genetic cancer risk” on to their children. Knowing whether or not a family member’s cancer was due to known inherited factors can help alleviate this anxiety, as children have a 50% chance of NOT inheriting the marker and are thus not at increased risk.
- There are numerous studies completed (with other studies ongoing) showing that cancer patients with the KRAS-variant respond to specific chemotherapy approaches, and not to others. Please see MiraDx for additional information.
I don't have the KRAS-variant and I've never been diagnosed with cancer.
- If you have a family history of breast or ovarian cancer (your family is a HBOC family) and you are also negative for BRCA, your test suggests that you might not have inherited a genetic risk for cancer.
- If you do not have other known cancer-causing mutations, your test result indicates you are at the same or lower risk of developing ovarian, breast or lung cancer than the general population.
I don't have the KRAS-variant but I've been diagnosed with breast or ovarian cancer.
- A negative test result does not mean that there is no genetic explanation for your cancer. It only indicates that it was not the KRAS-variant.
- If you do not have other known cancer-causing mutations, you do not need to worry about a poor treatment response to platinum due to the KRAS-variant.