HRT and The KRAS-Variant


While there are many factors to consider before taking hormone replacement therapy (HRT), understanding your genetic profile can prove invaluable in your decision-making process. Joanne Weidhaas, MD, PhD, and her colleagues published research in 2015 that pointed to estrogen withdrawal—which occurs during menopause, abrupt stoppage of HRT, or a pre-menopausal oophorectomy without HRT—as a potential trigger for the onset of cancer in women who carry an inherited genetic mutation known as the KRAS-variant.

For women who do test positive for the KRAS-variant, maintaining one’s estrogen levels via hormone replacement therapy through peri-menopause and into menopause appears to be protective in decreasing cancer risk.

While any decision around prescription HRT should involve a consultation and discussion with your physician, if you are a woman experiencing menopausal symptoms and are trying to decide whether to go on or stay on HRT, you may want to consider getting tested for the KRAS-variant.  Regardless of whether you test positive or negative, the result will provide you with a powerful piece of genetic information to help inform this important decision about your health.


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Any discussion of medical management options on this website is for general informational purposes only and does not constitute a medical recommendation. All medical management decisions should be made based on consultation between each patient and his or her healthcare professional.

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