KRAS-VARIANT TESTING INFORMATION

Knowing if you have the KRAS-variant can help you reduce your risk of cancer. 

If you have already been diagnosed with cancer, knowing if you have the KRAS-variant can help you and your doctor determine the best treatments and prevention for future cancers.

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Getting tested for the KRAS-variant

We recommend getting tested for the KRAS-variant if:

Click on an option for more details.

Your body's estrogen levels are decreasing, for example you may be:
  • Perimenopausal or menopausal, typically around the age of 40
  • Considering starting or discontinuing hormone replacement therapy (HRT)iMedication that replaces the estrogen your body stops making during menopause.
  • Considering an oophorectomyiThe surgical removal of one or both ovaries.
You have cancer
You have a family history of cancer
  • Also if you have a family history of cancer and are BRCA-negativeiThe name “BRCA” is an abbreviation for “BReast CAncer gene.” BRCA1 and BRCA2 are two different genes that have been found to impact a person's chances of developing breast cancer.

The KRAS-variant is an inherited genetic mutation associated with breast cancer,3 ovarian cancer,2 lung cancer,1 as well as other cancers,5,6 and multiple cancers in the same individual.4,7

Your body's estrogen levels are decreasing

Your body's estrogen levels are decreasing

During menopause, you go through a natural process that reduces the amount of estrogen in your body. Also, if you have an oophorectomyiThe surgical removal of one or both ovaries., your body’s estrogen levels will drop. Estrogen can protect individuals with the KRAS-variant7 from getting cancer, so knowing if you have the KRAS-variant puts you in the best position to make informed choices that can reduce your risk for certain cancers.

You have cancer

You have cancer

If you have cancer, certain medications are far more effective for KRAS-variant cancer patients, and can lead to over a 300% improvement in survival and cure.22,23

Additionally, women with the KRAS-variant have an elevated risk of an independent second cancer.4 Knowing if you have the KRAS-variant will help you and your doctor decide the best screening and management strategies to minimize that risk.

You have a family history of cancer

You have a family history of cancer

If you have a family history of cancer, knowing your KRAS-variant status will help you understand your familial cancer. The KRAS-variant is 20x more common than the much more well-known BRCA variant,17,18 so if you are BRCA-negative, the KRAS-variant may explain why cancer runs in your family.

If you test positive, you’ll be able to tell your other family members to get tested, so they can also mitigate their risk for cancer or treat cancer they may have. On the other hand, if you test negative you'll know the KRAS-variant is not responsible for your family's cancer.

KRAS-variant testing options

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    Join a MiraKind study & learn your KRAS-variant status

    If you join a study, you may learn your KRAS-variant status* for $129, which covers the basic costs of processing the test. If you need financial assistance, you may request it when you order.

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    Learn your KRAS-variant status

    Learn your KRAS-variant status* for $159.

*Your individual KRAS-variant results will be sent to a physician of your choice.

How to get tested for the KRAS-variant

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Place Your Order

Order through MiraDxiKRAS-variant testing is performed through our sister company MiraDX in their CLIA-approved laboratory. and they will ship the test to you directly.

In the order form, you will choose to have the results sent to your personal physician or sent to an OB/GYN at our partner, GenneviGennev is a national group of OBGYNs who are educated about the KRAS-variant and the best management for patients who have the KRAS-variant.
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Take the Test & Return

Take the test as directed and ship it back to MiraDxiKRAS-variant testing is performed through our sister company MiraDX in their CLIA-approved laboratory.

Once the MiraDx lab has received the test, your selected physician will receive your results within a week.

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Meet with Your Doctor

You will make an appointment with your doctor to receive your results and discuss your next steps.

You will have the option to enroll in a study or not when you order your test.

If you have questions about KRAS-variant testing, you can read FAQs here.

Receiving and interpreting your KRAS-variant results

Once your results are ready, you will need to discuss your results with a physician. You can talk to your doctor or you can make a virtual one-on-one appointment with an OB/GYN or nurse practitioner at genneve.com.

Gennev is a national group of OBGYNs who are educated about the KRAS-variant and the best management for patients who have the KRAS-variant.

Interpreting your KRAS-variant results
Interpreting your KRAS-variant results

“I have the KRAS-variant but I've never had cancer.”

Knowing you carry the KRAS-variant provides you and your doctor with powerful information that can be used to help minimize your risk of cancer.

  • If you are perimenopausal, menopausal or are having your ovaries removed, you can help prevent cancer by maintaining healthy estrogen levels through hormone replacement therapy (HRT), and you’ll need to discuss that with your doctor.7
  • Work with your doctor to get higher level breast cancer screening (e.g. a breast MRI or ultrasound in addition to regular mammograms).
  • Continue gynecological screening of your ovaries, and consider the option to have outpatient surgery to remove the fallopian tubes and ovaries if and when you and your physician think it is most appropriate.
  • If you are planning to have a hysterectomy, you may want to speak with your doctor about removing your ovaries at the same time.
  • If you smoke, it’s especially important to consider strategies for stopping, as smoking further elevates your risk for cancer.
  • Actions you can take depending on your age:
    • In your 40s and 50s
      • Consider higher-level breast cancer screening, such as breast MRIs, in addition to annual mammograms.
      • If having a hysterectomy consider ovary removal with follow-up HRT.
      • Discuss hormone replacement therapy while you are still peri- menopausal with your doctor to help protect against cancer.
      • Consider ovary removal after menopause.
    • In your 60s
      • Continue ongoing gynecological care.
      • Continue on hormone replacement therapy.
    • In your 70s and beyond
      • Use your KRAS-variant status to continue breast and gynecological screening.

“I have the KRAS-variant and I have been diagnosed with cancer.”

Your cancer diagnosis could be associated with this genetic difference1-7 Together with your physician, you can now use the information in several ways to protect your health and inform your decision making going forward.

  • Your body will respond uniquely to cancer therapy, and you can be directed to the best treatment options for you.22,23
  • You may be at an elevated risk of an independent second cancer,4 so it is important to discuss the best screening and management strategies with your physician to minimize this risk.
  • Tell your family members, so they can also be tested for the KRAS-variant. Your children only have a 50% chance of inheriting the marker.

“I don't have the KRAS-variant and I've never been diagnosed with cancer.”

  • If you have a family history of breast or ovarian cancer (your family is a HBOC family) and you are also negative for BRCA, your test suggests that you might not have inherited a genetic risk for cancer.
  • If you do not have other known cancer-causing mutations, your test result indicates you are at the same or lower risk of developing ovarian, breast or lung cancer than the general population.

“I don't have the KRAS-variant but I've been diagnosed with breast or ovarian cancer.”

  • A negative test result does not mean that there is no genetic explanation for your cancer. It only indicates that it was not the KRAS-variant.
  • If you do not have other known cancer-causing mutations, you do not need to worry about a poor treatment response to platinum due to the KRAS-variant.
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