What is the KRAS-Variant 

THE KRAS-VARIANT

What is the KRAS-Variant

The KRAS-variant belongs to a new class of inherited genetic variants that predict increased risk of cancer.1-6 We have helped show that this new type of genetic variant can be impacted by lifestyle choices. For women with the KRAS-variant, cancer may be prevented by maintaining estrogen levels.7

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The KRAS-variant

The KRAS-variant is an example of a new type of biomarker that can explain the genetic cause of cancer for many more families with strong cancer histories.

The KRAS-variant is found in up to 25% of cancer patients, making it far more common than previously known genetic variants associated with cancer, such as BRCA1, which is found in only 5% of breast and ovarian cancer patients. 17,18

bar chart that shows many more cancer cases are now have hereditary causes than previously thought before the KRAS-variant
Sporadic

Sporadic Cancer

Cancer that occurs without known family history or an inherited genetic difference.

Hereditary

Hereditary Cancer

Cancer caused by known inherited genetic variants such as BRCA or CHEK2.

Familial

Familial Cancer

Cancer that occurs in families more often than would be expected by chance, but there is no known genetic reason.

The scientific breakthrough that led to the discovery of a new type of genetic variant

In your cells, your DNA is continuously converting into molecules (called RNA), which then become proteins. These proteins serve many vital functions in your body.19 However in recent years, scientists have discovered that DNA also makes RNA molecules that never turn into proteins. These molecules are called non-coding RNAs and some of them appear to “control” what and how proteins are used throughout your body.20

This discovery has changed the fundamental understanding of biology, and has also led to new findings, like the KRAS-variant.

The KRAS-variant explains a large percentage of hereditary cancers

While it had been believed that most cancer was due to chance, as only 5-10% of cancers had known hereditary causes,21 we have now found that much more of cancer risk is passed down from your parents.

Our work at MiraKind is to discover the genetic variants for many more cancers, and to use this information to define the strategies and behaviors that may help reduce cancer risk.

graphic that states: the KRAS-variant causes up to 55% of hereditary cancer
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What the KRAS-variant may mean for your health

Patients with the KRAS-variant are at a higher risk of developing cancer.1-6 Our studies show that women with the KRAS-variant can reduce cancer risk by maintaining their estrogen levels.7

The KRAS-variant was discovered in 2006, and MiraKind’s research studies are helping us learn more about its implications for health and cancer risk every day. However, we have already learned some important things about how individuals with the KRAS-variant may be able to use information about their KRAS-variant status to help them make decisions about their health. Learn more about the KRAS-variant if you have a family history of cancer, cancer, or are peri- or menopausal.

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Who should get tested for the KRAS-variant?

If you have a family or personal history of cancer, or are a female who is peri- or menopausal, you may want to get tested for the KRAS-variant.

Getting tested for the KRAS-variant provides information that you and your doctor can use to make informed decisions about your health.

Learn more about why and how to get tested here.

Graphic that states: The KRAS-variant is an inherited genetic variant associated with an increased risk of breast, ovarian and lung cancer
You can help by joining a study

Why join a MiraKind research study?

By joining a MiraKind study, you can play a role in helping MiraKind answer some of the most pressing questions associated with cancer risk for individuals with inherited variants like the KRAS-variant. Your participation in a study helps us get closer to finding the answers to improve health for all individuals with this new class of genetic variant.

Learn more about joining a study here.

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want to help?

By joining a MiraKind study, you can play a role in helping MiraKind answer some of the most pressing questions associated with cancer risk and prevention for individuals with the KRAS-variant.

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The world of genetics and medicine continues to evolve. Education is one of the foundations of MiraKind. We will provide you regular updates in an easily digestible format.

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