Why you should get your KRAS-variant results

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Why you should get your KRAS-variant results

Dear study participants,

I wanted to share an experience that I had today. I had a wonderful conversation with a woman who participated in the first MiraKind study.  While I always enjoy speaking with study participants, I had very mixed emotions about this conversation, because I was discussing her KRAS-variant results with her – and she is positive.

The very hard part of the conversation is that this woman has recently been diagnosed with advanced ovarian cancer. She is a 10 year + survivor of her breast cancer, and now is dealing with this. I struggled with the fact that things may have been different if she knew that she was KRAS-variant positive sooner… maybe her doctor would have followed her more closely, maybe she would have picked up a concerning symptom if she was on the look out.

Please consider getting your KRAS-variant results, especially if you have been previously diagnosed with cancer.  KRAS-variant patients are at a significantly elevated risk of a second cancer, either breast or ovarian.  50% of women with both breast and ovarian cancer that are BRCA negative have the KRAS-variant, and there is up to a 16 fold increased risk of a second breast cancer after the first.  If you can not afford the testing fee, ask for financial assistance, you will get it.




Reader Interactions


  1. Dear All, I would second the “find out” recommendation. I took part in the first study and did not bother getting my results, then. In May I had a 1.8 cm tumor removed from my right lung, at Bethesda they test for KRAS now. 15 years ago I quit smoking. 11 years ago I was treated for a 9 cm lobular breast cancer. I lucked out on breaking ribs to find the lung cancer. Find out if you can!

    • Dear Mrs. Bell
      Thank you for sharing your experience! This is exactly our hope, that women will share their strength and hope. Please let me know if there is anything I can ever do to help.

  2. I am a 5 year survivor of breast cancer via bilateral mastectomy and radiation. I consider myself lucky as it was very early stages. I also had a mole removed that was high risk for melanoma, a hair shade away as they put it. I am KRAS variant positive. Since learning I was positive, I found out I had an ovarian polyp that had been growing for 5 years. I knew I was at greater risk for ovarian cancer so I agreed to an oopherectomy. Thankfully, all of this occurred after I had 5 children and did not necessarily need all these body parts. But, I constantly worry where else the cancer cells may appear, how to prevent them from growing. I have revamped my diet, excluding soy and sugar in hopes of not allowing the cancer cells to have an environment in which to grow but I am uncertain if that will stop them or if this mutation will allow them to keep growing. My question is, where do I go from here with this knowledge?

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