Why you should get your KRAS-variant results


Dear study participants,

I wanted to share an experience that I had today. I had a wonderful conversation with a woman who participated in the first MiraKind study.  While I always enjoy speaking with study participants, I had very mixed emotions about this conversation, because I was discussing her KRAS-variant results with her – and she is positive.

The very hard part of the conversation is that this woman has recently been diagnosed with advanced ovarian cancer. She is a 10 year + survivor of her breast cancer, and now is dealing with this. I struggled with the fact that things may have been different if she knew that she was KRAS-variant positive sooner… maybe her doctor would have followed her more closely, maybe she would have picked up a concerning symptom if she was on the look out.

Please consider getting your KRAS-variant results, especially if you have been previously diagnosed with cancer.  KRAS-variant patients are at a significantly elevated risk of a second cancer, either breast or ovarian.  50% of women with both breast and ovarian cancer that are BRCA negative have the KRAS-variant, and there is up to a 16 fold increased risk of a second breast cancer after the first.  If you can not afford the testing fee, ask for financial assistance, you will get it.



Join our mailing list for news and updates about our research and women’s health!

  • This field is for validation purposes and should be left unchanged.




  • Dear All, I would second the “find out” recommendation. I took part in the first study and did not bother getting my results, then. In May I had a 1.8 cm tumor removed from my right lung, at Bethesda they test for KRAS now. 15 years ago I quit smoking. 11 years ago I was treated for a 9 cm lobular breast cancer. I lucked out on breaking ribs to find the lung cancer. Find out if you can!

    • Dear Mrs. Bell
      Thank you for sharing your experience! This is exactly our hope, that women will share their strength and hope. Please let me know if there is anything I can ever do to help.

  • I am a 5 year survivor of breast cancer via bilateral mastectomy and radiation. I consider myself lucky as it was very early stages. I also had a mole removed that was high risk for melanoma, a hair shade away as they put it. I am KRAS variant positive. Since learning I was positive, I found out I had an ovarian polyp that had been growing for 5 years. I knew I was at greater risk for ovarian cancer so I agreed to an oopherectomy. Thankfully, all of this occurred after I had 5 children and did not necessarily need all these body parts. But, I constantly worry where else the cancer cells may appear, how to prevent them from growing. I have revamped my diet, excluding soy and sugar in hopes of not allowing the cancer cells to have an environment in which to grow but I am uncertain if that will stop them or if this mutation will allow them to keep growing. My question is, where do I go from here with this knowledge?

    • Dear Jodie
      It was great speaking to you about this. As we discussed, you are doing everything you should be!


Leave a Reply

Your email address will not be published. Required fields are marked *


Any discussion of medical management options on this website is for general informational purposes only and does not constitute a medical recommendation. All medical management decisions should be made based on consultation between each patient and his or her healthcare professional.

arrow up to top