Cancer + The KRAS-Variant

The KRAS-variant may help determine the best treatment for the 20-25% of cancer patients who carry this biomarker.


The KRAS-variant is NOT a KRAS mutation in a cancerous tumor. KRAS mutations in a tumor are not inherited. You can learn more about the difference between the KRAS-variant and KRAS mutations here.

In fact, recent research has shown that the KRAS-variant plays an important role in the body's response to cancer therapies by affecting an individual's immune system.

Specifically, studies have found that certain cancer medications are far more effective for KRAS-variant cancer patients, while others work poorly. The difference in taking the wrong versus the right cancer medicine if you are a KRAS-variant patient can lead to up to a 3-fold (300%) difference in your chance of survival.22,23

Research to determine which treatments work best for KRAS-variant patients have been conducted in breast,3 ovarian,22,25 colon,26-37 lung, and head and neck cancer.23,40,41 To read publications with findings about specific types of cancers, please go here.

The KRAS-variant is an inherited genetic variant associated with breast cancer,3 ovarian cancer,2 lung cancer,1 as well as other cancers,5,6 and multiple cancers in the same individual.4,7

Should you get tested for the KRAS-variant?

If you have history of breast, ovarian or lung cancer, learning whether you have the KRAS-variant can help you make the important decision about whether or not HRT is right for you.

Learn more about why and how to get tested here.

graphic that states: Hormone Replacement Therapy reduces the risk of cancer for women with the KRAS-variant

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The world of genetics and medicine continues to evolve. Education is one of the foundations of MiraKind. We will provide you regular updates in an easily digestible format.



Any discussion of medical management options on this website is for general informational purposes only and does not constitute a medical recommendation. All medical management decisions should be made based on consultation between each patient and his or her healthcare professional.

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