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Approximately, 75% of women experience symptoms of menopause, including hot flashes and night sweats, which can last an average of five years. Hormone replacement therapy (HRT) has long been known as the most effective treatment for these symptoms.
Unfortunately, HRT’s use decreased dramatically after the 2002 Women’s Health Initiative Study reported an association between HRT and worse health outcomes, including increased breast cancer risk.
However, follow up studies indicated that there were subgroups of women for whom estrogen decreases breast cancer risk. These subgroups remained to be identified, until recently.
A recent MiraKind study showed that estrogen withdrawal, which occurs after oophorectomy (the removal of both ovaries), with the discontinuation of HRT, or at menopause, may increase cancer risk in women with the KRAS-variant.1 These findings indicate continuing estrogen with HRT may be beneficial for women with the KRAS-variant in these settings, if not otherwise contraindicated. It also suggests that KRAS-variant women may be a subgroup who are protected from cancer development through continued estrogen use.
The KRAS-variant is an inherited genetic mutation associated breast cancer,1 ovarian cancer,4 lung cancer,5 as well as other cancers,6,7 and multiple cancers in the same individual.8,9
MiraKind’s research is focused on better understanding the lifestyle and environmental factors that impact cancer risk for KRAS-variant individuals so that they may make informed decisions to protect their health. Learn more about MiraKind’s open or future research studies that may be relevant to you.
If you are on or considering hormone replacement therapy, you are eligible for our studies as well as KRAS-variant testing. If you would like to join a study, please follow this link. You will be able to choose to get your KRAS-variant results at a discounted cost ($195) at the completion of the survey. If you would prefer to directly order KRAS-variant testing at cost ($295) without joining a study, please follow this link.