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What is the Role of Hormone Replacement Therapy in Breast Cancer Risk?

Dating back to 2002, there have been several studies stating that hormone replacement therapy (HRT) increases the risk for breast cancer. HRT was vilified, and many women stopped using or never started using HRT.

However, those findings do not apply to all women.

Here at MiraKind, we study recently discovered genetic mutations. One mutation, the KRAS-variant, was discovered in 2007, and MiraKind’s research studies are helping us learn more about its implications for health and cancer risk every day.

For women with the KRAS-variant, HRT may be of a particular benefit.

Declining estrogen levels appear to trigger aggressive high-risk breast cancer in women with the KRAS-variant.1 Therefore, we are proponents of HRT as a cancer prevention method for women with the KRAS-variant, considering other risks and benefits.

We are launching a new research study to further understand how hormone therapy decreases the risk of cancer in women with the KRAS-variant, and to identify other women for whom HRT may impact cancer risk.

If you are a woman 35 years or older, you are eligible for this study.

Take a quick survey and help us find better answers about the HRT and Breast Cancer connection for you and future generations.

It only takes about 5 minutes.

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About MiraKind

MiraKind was founded as a nonprofit research organization in 2013 by Joanne Weidhaas, MD, PhD., following her discovery of the KRAS-variant, an inherited genetic mutation associated with an increased risk of cancer, especially for women.

More about the KRAS-VARIANT

The KRAS-variant is one of the most frequently identified inherited genetic markers associated with cancer. The latest research indicates the KRAS-variant shows great potential to guide disease prevention and management across cancer types through its unique interactions with hormones and cancer therapies.

Facts about the KRAS-variant:

  • Cancer risk may be triggered by estrogen withdrawal
  • Found in 6-10% of the population
  • Predicts sensitivity and resistance to several standard-of-care cancer treatments/therapies