COVID-19 Testing for the Essential Workforce
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In our patient-centric studies, we seek to identify treatments that are the most effective with the fewest side effects for individuals who carry microRNA-disrupting mutations. Our first example, the KRAS-variant, has been shown to be is a powerful biomarker that can significantly predict sensitivity and resistance to specific cancer treatments, regardless of tumor type.
Specifically, knowing whether an individual carries this genetic mutation can help identify them as a responder or non-responder to therapies being used today. In addition, recent work has shown that the KRAS-variant is a strong biomarker of baseline immune status and inflammatory response. This has led us to apply this class of mutation to developing immunotherapies.
Research is ongoing to develop the best approaches for treating cancer patients with the KRAS-variant, as well as with other mutations in its class. By applying the information we have learned from this class of biomarkers, we can make a significant leap forward in personalizing cancer therapy.
The biology of the KRAS-variant, an inherited genetic mutation, affords great promise for treating cancer in the 20-25% of cancer patients who carry this biomarker.
In fact, recent research has shown that the KRAS-variant plays an important role in the body’s response to cancer therapies by affecting an individual’s immune system. Specifically, studies have found that certain cancer medications are far more effective for KRAS-variant cancer patients, while others do not work well. Research to determine which treatments work best for KRAS-variant patients have been conducted in breast,1 ovarian,2,3 colon,4-17lung,18,19 and head and neck cancer.21-23
Currently, there is a prospective clinical trial being conducted at UCLA for KRAS-variant/HPV+ head and neck cancer patients (HNSCC).
Learn more about links between the KRAS-Variant and specific Cancer Diagnoses.
Read findings about specific types of cancers, please review our scientific publications.